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Lecture 8 Grasping Cells

捕获细胞

日期: 2022-05-20 点击:

Speaker Bio


G. K. Ananthasuresh is Professor of Mechanical Engineering and the Dean of the Division of Mechanical Sciences at the Indian Institute of Science, Bengaluru, India. His research interests are in mechanical design, compliant mechanisms, MEMS, topology optimization, biomedical devices, and cell mechanics. Eight of his former students have become academicians, four are entrepreneurs who have founded startups, and many work in the industry.

G. K. Ananthasuresh教授是印度班加罗尔地区印度科学院机械工程教授和机械科学部主任。主要研究方向为机械设计、柔顺机构、MEMS、拓扑优化、生物医学设备和细胞力学。培养的学生中有8人成为了院士,4人是创业家,还有很多人在工业界工作。

Abstract

There is increasing evidence that mechanical response of biological cells changes when a cell is under disease conditions. Correlating the changed mechanical response to a specific disease condition paves the way for mechano-diagnostics as much as it would help understand a disease from the viewpoint of biomechanics. In this talk, we will discuss the micromachined tools and computational techniques developed in assessing the mechanical responses of single cells, suspended or adhered, in their native medium. The prospects for mechano-diagnostics will be outlined and some examples will be discussed in detail.

越来越多的证据表明,当细胞处于疾病状态时,生物细胞的机械性能会发生变化。通过将力学性能的变化与特定的疾病条件联系起来,为力学诊断铺平了道路,也有助于从生物力学的角度理解疾病。这次报告将讨论如何将微机械工具和计算机技术用以评估悬浮或粘附在自然介质中单细胞的力学反应,并将详细讨论力学诊断的前景和应用案例。