Speaker Bio

Guy M. Genin is a professor in the Department of Mechanical Engineering and Materials Science at Washington University in St. Louis. Dr. Genin graduated from Harvard University and now is also a professor in Xi'an Jiaotong University. Prof. Guy is an outstanding researcher in the fields of interface mechanics of bone-tendon interface, cell-ECM interface and plant mechanics. Prof. Genin have published more than 100 papers in the top journals (e.g., Nature Materials, Nature Method, and Circulation Research), 1 monograph, 10 chapters, and 2 cooperative books. Prof. Genin also have 2 US invention patents. In recent years, Prof. Genin realized the substantial promotion and advancement of the interdisciplinary intersection of mechanical, material and biomedical engineering in Xi'an Jiaotong University in China.

圣路易斯华盛顿大学机械工程与材料科学系教授,毕业于哈佛大学。Genin 教授与中国西安交通大学开展了多年卓有成效的项目合作研究，并在骨-肌腱界面力学、细胞粘附力学和植物细胞防御力学等方面取得突破性进展。研究成果在领域内顶级期刊Nature Material、Nature Method、Circulation Research等发表论文100余篇，出版专著1部，专著章节10篇，合作编书2部，获授权美国发明专利2项。实现了国内机械、材料、生物医学工程的学科交叉的实质性促进和推动。

Abstract

Fibrotic disease is incurable and afflicts nearly all of the elderly, with sequelae that can include organ failure and certain cancers. An early stage of much fibrotic disease is the triggering of signals for the wound-healing process, which causes conversion of fibroblast cells to contractile and proliferative myofibroblasts. Recent progress in the field of mechanobiology, enabled in part by materials innovation at Xi’an Jiaotong University, has let to new insight into the mechanisms underlying this pathological conversion, and to new ways that mechanics may be modulated to prevent it. This talk will present our ongoing work to unravel the mechanics of fibrosis and to identify pathways for prevention and cures.

组织纤维化几乎困扰着所有的老年人，目前仍存在治疗效果不佳，预后差等难题。此外，由其导致的后遗症，包括器官衰竭及伴随产生的癌症同样严重影响人体健康。在纤维化发生发展的早期阶段，成纤维细胞发生表型转化，通过激活伤口愈合信号途径转化为具有较强收缩性和增殖活性更高的肌成纤维细胞。随着力学生物学领域的不断发展，包括西安交通大学在内研究机构开发了具有独特力学性能的生物材料，使得对组织纤维化早期阶段发生的细胞表型转化机制有了新的认识，并找到了可以通过力学生物学手段对组织纤维化防治的新方法。本讲座将介绍我们正在进行的工作，以解开纤维化的机制并确定预防和治疗的途径。